Transdermal study of hydrogel ointments and bandages with antituberculosis activity

Authors

  • M. S. Buribayeva Al-Farabi Kazakh National University, Kazakhstan, Almaty
  • A. Kunakbayeva Al-Farabi Kazakh National University, Kazakhstan, Almaty
  • L. Abebova Al-Farabi Kazakh National University, Kazakhstan, Almaty
  • G. S. Irmukhametova Al-Farabi Kazakh National University, Kazakhstan, Almaty
  • K. B. Muldagulova Al-Farabi Kazakh National University, Kazakhstan, Almaty
  • G. A. Mun Al-Farabi Kazakh National University, Kazakhstan, Almaty

DOI:

https://doi.org/10.26577/2218-7979-2015-8-1-73-78

Keywords:

transdermal therapeutic system, drug delivery, polyvinylpyrrolidone, isoniazid, ethambutol, carbomer

Abstract

Transdermal study for hydrogel ointments and bandages based on polyvinylpirrolidone was conducted for application as transdermal therapeutic drug delivery systems for skin tuberculosis treatment. The ointments and bandages based on polyvinylpyrrolidone (PVP) and carbomer with drugs isoniazid and ethambutol were obtained. The transdermal characteristics were investigated using cellulose membrane and pig skin. The experiment was carried out by the device Franz cell and diffusion coefficient (D), permeability (P) and permeation rates (F) of the drugs were calculated. It was established that the rate of isoniazid penetration through the skin faster than that for ethambutol which is related to the structure peculiarities of drugs. The higher transdermal activity of hydrogel ointments was shown in comparison with hydrogel dressings. Also the prolongation effect of developed transdermal drug delivery systems based on PVP and carbomer was observed.

References

1 Jasti BR, Abraham W, Ghosh TK. Transdermal and Topical drug delivery systems. In: Ghosh TK, Jasti BR, editors. Theory and Practice of Contemporary Pharmaceutics. 1st ed. Florida: CRC Press; 2005. p. 423-53.

2 Baker H. The skin as barrier. In: Rook A, Wilkinson DS, Ebling FJG, Champion RH, Burton JL, eds. Text Book of Dermatology. Vol. I, 4th ed.
Oxford: Blackwell Scientific Publications, 1986:355-66.

3 Barr M. Percutaneous absorption, J Pharm Sci 1962; (61):395-409.

4 Chein YW. Advances in transdermal systemic drug delivery. Drugs of Future 1988; (13):343-62.

5 N. Blanchin, S. Desloires, L. Grappin, A.M. Guillermin, P. Lafon, A. Miele, Protocols in an occupational medical facility for the management of internal plutonium exposure incidents in a nuclear plant:
development–application–analysis–validation from 1996 to 2002, Radioprotection 39 (2004) 59–75.

6 B.M. De Rey, H.E. Lanfranchi, R.L. Cabrini, Percutaneous absorption of uranium compounds, Environ. Res. 30 (1983) 480–491.

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Published

2015-06-30

How to Cite

Buribayeva, M. S., A. Kunakbayeva, L. Abebova, G. S. Irmukhametova, K. B. Muldagulova, and G. A. Mun. 2015. “Transdermal Study of Hydrogel Ointments and Bandages With Antituberculosis Activity”. International Journal of Biology and Chemistry 8 (1):73-78. https://doi.org/10.26577/2218-7979-2015-8-1-73-78.