Transdermal study of hydrogel ointments and bandages with antituberculosis activity

  • M. S. Buribayeva Al-Farabi Kazakh National University, Kazakhstan, Almaty
  • A. Kunakbayeva Al-Farabi Kazakh National University, Kazakhstan, Almaty
  • L. Abebova Al-Farabi Kazakh National University, Kazakhstan, Almaty
  • G. S. Irmukhametova Al-Farabi Kazakh National University, Kazakhstan, Almaty
  • K. B. Muldagulova Al-Farabi Kazakh National University, Kazakhstan, Almaty
  • G. A. Mun Al-Farabi Kazakh National University, Kazakhstan, Almaty

Abstract

Transdermal study for hydrogel ointments and bandages based on polyvinylpirrolidone was conducted for application as transdermal therapeutic drug delivery systems for skin tuberculosis treatment. The ointments and bandages based on polyvinylpyrrolidone (PVP) and carbomer with drugs isoniazid and ethambutol were obtained. The transdermal characteristics were investigated using cellulose membrane and pig skin. The experiment was carried out by the device Franz cell and diffusion coefficient (D), permeability (P) and permeation rates (F) of the drugs were calculated. It was established that the rate of isoniazid penetration through the skin faster than that for ethambutol which is related to the structure peculiarities of drugs. The higher transdermal activity of hydrogel ointments was shown in comparison with hydrogel dressings. Also the prolongation effect of developed transdermal drug delivery systems based on PVP and
carbomer was observed.

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Published
2015-06-30
How to Cite
BURIBAYEVA, M. S. et al. Transdermal study of hydrogel ointments and bandages with antituberculosis activity. International Journal of Biology and Chemistry, [S.l.], v. 8, n. 1, p. 73-78, june 2015. ISSN 2409-370X. Available at: <http://ijbch.kaznu.kz/index.php/kaznu/article/view/179>. Date accessed: 20 apr. 2019. doi: https://doi.org/10.26577/2218-7979-2015-8-1-73-78.

Keywords

transdermal therapeutic system; drug delivery; polyvinylpyrrolidone; isoniazid; ethambutol; carbomer