Preclinical study of “Microfit” probiotic preparation influence on internals of laboratory rats

  • K. D. Zakarya RSE on the REI «Republic Collection of Microorganisms» CS MES
  • Z. S. Sarmurzinа RSE on the REI «Republic Collection of Microorganisms» CS MES
  • R. T. Dospaeva RSE on the REI «Republic Collection of Microorganisms» CS MES
  • G. N. Bissenova RSE on the REI «Republic Collection of Microorganisms» CS MES
  • Z. T. Shulgau RSE on the REI “National Center of Biotechnology” CS MES
  • A. E. Gulyaev RSE on the REI “National Center of Biotechnology” CS MES
  • T. N. Krivoruchko RSE on the REI “National Center of Biotechnology” CS MES
  • B. B. Zhetpisbaev JSC «National Center of Neurosurgery»

Abstract

Histologic research is one of the most reliable methods of diagnosis of pathologies of organs and tissues. This method allows estimating both macroscopic and microscopic structural changes in organs and tissues of animals. Data obtained in the course of the pathomorphological research have fundamental value for studying toxic influence of preparations at the stage of preclinical research. Results of histologic structure of internals and tissues of laboratory Sprague Dawley rats are presented in this article. As a result of experiments it has been established that no side effects have been revealed at preparation administration toanimals. “Microfit” biological preparation exerted no negative impact on functional activity of internals of an organism of rats, caused no allergic reactions. The macroscopic research of internals of all experimental animals revealed no pathology after autopsy. Pathomorphological research of the main organs and tissues confirms safety of the structure of tissues. Following the research results, within one month (30 days) of administration of the biological preparation, it has been established that in case of course intragastric administration of “Microfit” preparation to white Sprague Dawley rats in a conditional-therapeutic dose (30 mg/kg) and a dose exceeding the conditional-therapeutic dose by 10 times (300 mg/kg), the preparation has no toxic effect on condition of internals and tissues.
Published
2017-12-29
How to Cite
ZAKARYA, K. D. et al. Preclinical study of “Microfit” probiotic preparation influence on internals of laboratory rats. International Journal of Biology and Chemistry, [S.l.], v. 10, n. 2, p. 34-39, dec. 2017. ISSN 2409-370X. Available at: <http://ijbch.kaznu.kz/index.php/kaznu/article/view/284>. Date accessed: 15 dec. 2018. doi: https://doi.org/10.26577/2218-7979-2017-10-2-34-39.