Chemical constituents of Dracocephalum nutans
DOI:
https://doi.org/10.26577/2218-7979-2015-8-2-90-97Keywords:
Dracocephalum nutans, chemical constituent, Altay region, quantitative and qualitative analysis, Volatile oils, GC–MSAbstract
In this study we investigate the chemical constituent in aerial parts of Dracocephalum nutans. The moisture content (6.13%), total ash (2.18%), extractives (35.25%) and quantitative and qualitative analysis of biologically active constituents of aerial parts of Dracocephalum nutans were determined. In The Institute of Combustion Problems using the method of multi–element atomic emission spectral analysis in the ash of Dracocephalum nutans were found 11 macro–micro elements, main of them was K(794.5750 μg/ml), Ca (440.63 μg/ml), Fe (4.5005 μg/ml), Zn (1.6911 μg/ml). The volatile oil constitutes were extracted from the aerial parts of Dracocephalum nutans by water steam distillation were analyzed by GC–MS method. More than forty compounds were separated. Their relative contents were determined by area normalization in which 45volatiles were identified. The major volatile oils of 1H–Cycloprop[e] azulen – 7 – ol, decahydro – 1, 1, 7 – trimethyl – 4 – methylene – (14.23%), Caryophyllene oxide (11.30%), 1, 6 – Octadien – 3 – ol, 3, 7 – dimethyl – (7.69%), (–) – myrtenyl acetate (5.67%), Naphthalene, 1, 2, 3, 4, 4A, 5, 6, 8A – octahydro – 7 – methyl – 4 – methylene (5.29%), (–) – spathulenol (4.76%), Benzene, 1 – methoxy – 4 – (1 – propenyl) – (4.73%), 4 ah – cycloprop [e]azulen – 4A – ol, decahydro – 1, 1, 4, 7 – tetra – [ethenyl] – (4.65%), Germacrene D (4.42%), (E) – 3(10) – caren – 4 – ol (4.23%), Bicyclo [7.2.0] undec – 4 – ene, 4, 11, 11 – trimethyl – 8 – methulene – (3.67%), α –Caryophyllene (3.60%), 12 – oxabicyclo [9.1.0] dodeca – 3, 7 – diene, 1, 5, 5, 8 – tetramethyl (2.13%).References
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2. P. Lazarevic, M. Lazarevic, Z. Krivosej, V. Stevanovic. On the distribution of Dracocephalum ruyschiana (Lamiaceae) in the Balkan Peninsula// Phytologia Balcanica. – 2009. – 15 (2). – P. 175-179, Sofia.
3. «Kazakhstan» National Encyclopedia // Kazakh Encyclopedia reduction, 1998.
4. S. Yousefzadeh, S. A. M. Modarres–Sanavy, F. Sefidkon, A. Asgarzadeh, A. Ghalavand, K.Sadat– Asilan. Effects of Azocompost and urea on the herbage yield and contents and compositions of essential
oils from two genotypes of dragonhead (Dracocephalum moldavica L.) in two regions of Iran//Food Chemistry. – 2013. – 138 (2013). – P. 1407-1413
5. Jay Prakash Rajan, Kshetrimayum Birla Singh, Sanjiv Kumar, Raj Kumar Mishra. Trace elements content in the selected medicinal plants traditionally used for curing skin diseases by the natives of Mizoram, India// Asian Pac J Trop Med. – 2014. –7(Suppl 1): – P. 410-414
6. Yong–Lak Park, Jun–Hyung Tak. Chapter 6 – Essential oils for arthropod pest management in agricultural production systems// Essential Oils in Food Preservation, Flavor and Safety. – 2016. – P. 61-70.
7. Sanjib Bhattacharya. Chapter 3 – Cultivation of essential oils // Essential oils in food preservation, flavor and safety. – 2016. – P. 19-29.
8. Xu X., Konirbay B., Jenis J., etal. The Kazakh Materia Medica, The Ethnic Press: Beijing, 2009. – P. 357.
9. Shahin Aziz, Koushik Saha, Nasim Sultana, Husna Parvin Nur, Md. Aminul Ahsan, Shamim Ahmed,Md. Kamal Hossain. Comparative studies of elemental composition in leaves and flowers of Catharanthus
roseus growing in Bangladesh // Asian Pac J Trop Biomed. – 2015. – 10(1016). – P.1-5.
10. A. Akpuaka, M.M. Ekwenchi, D.A. Dashak, A. Dildar. Biological activities of characterized isolates of n–hexane extract of Azadirachta indica A. Juss (Neem) leaves // Nature and Science, 2013.
–11(5). – P. 141-147.
11. M.J. Chavan, P.S. Wakte, D.B. Shinde. Analgesic and anti–inflammatory activity of Caryophyllene oxide from Annonasquamosa L. bark // Phytomedicine. – 2010. – 17(2). – P. 149-151.
12. Brared Christensson J., Forsström P., Wennberg A.M., Karlberg A.T., Matura M. Air oxidation increases skin irritation from fragrance terpenes// Contact Dermatitis. – 2009. – 60. – P. 32-40.
13. BraredChristensson J., Matura M., Backtorp C, Borje A., Nilsson J.L.G, Karlberg A.T. Hydroperoxides form specific antigens in contact allergy // Contact Dermatitis. – 2006. – 55(4). – P. 230-7.
14. Angélica Maria Sabogal–Guáqueta, Edison Osorio, Gloria Patricia Cardona–Gómez. Linalool reverses neuropathological and behavioral impairments in old triple transgenic Alzheimer’s mice // Neuropharmacology. – 2016. – 102. – P. 111-120.
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Baiseitova, A. M., H. Aisa, and J. Janar. 2015. “Chemical Constituents of Dracocephalum Nutans”. International Journal of Biology and Chemistry 8 (2):90-97. https://doi.org/10.26577/2218-7979-2015-8-2-90-97.
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