Effects of crude oil and its inorganic component (vanadium) on antioxidant enzymes in liver and kidneys of rats

  • T. M. Shalahmetova Al-Farabi Kazakh National University
  • K. E. Mahmoud Minoufiya University
  • Sh. N. Deraz Minoufiya University

Abstract

Antioxidant defense were studied in liver and kidney of male albino rats received an aqueous solution of ammonium metavanadate (AMV; 0.30 mg V/mL) or/and crude oil (CO; 0.75 ml/kg bw ip)) for 21-day period. AMV or/and CO treatments resulted in a significant (P<0.001) induction in aminotransferases (ALT and AST) activities in serum, as well as lipid peroxidation in liver and kidney. Concomitantly significant (P<0.001) decline in superoxide dismutase (SOD) activity and glutathione (GSH) content was obtained. In AMV and AMV-CO treatments, glutathione-S-transferase (GST) activity significantly (P<0.001) reduced in liver and induced in kidney while in CO treatment, GST activity significantly (P<0.01) induced in liver and was unchanged in kidney. Signs of toxicity were observed in all vanadium-treated animals as evidenced by some deaths, decreased weight gain. These data indicated that kidney is more vulnerable to the caused by the AMV or/and CO-induced oxidative stress than liver as well as that the oxidative stress at co-exposure to AMV and CO may be more markedly advanced than at separate exposure.

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Published
2012-06-20
How to Cite
SHALAHMETOVA, T. M.; MAHMOUD, K. E.; DERAZ, Sh. N.. Effects of crude oil and its inorganic component (vanadium) on antioxidant enzymes in liver and kidneys of rats. International Journal of Biology and Chemistry, [S.l.], n. 3, p. 27-33, june 2012. ISSN 2409-370X. Available at: <http://ijbch.kaznu.kz/index.php/kaznu/article/view/48>. Date accessed: 24 apr. 2019.

Keywords

Crude oil; Ciprofloxacin; Cytochrome P-450 1A; Lipid peroxidation; Rat