Natural antioxidants of plant origin
DOI:
https://doi.org/10.26577/2218-7979-2015-8-1-67-72Keywords:
antioxidant action, Limonium Mill, polyphenolsAbstract
In pharmacotherapy and prevention of “free radical diseases”, including diseases of the cardiovascular system, gastrointestinal tract, malignancies, herbal medicinal products become important, the effect of which is based on synergistic action of the major groups of natural compounds, such as polyphenols (mainly condensed tannins and flavonoids), amino, phenolic, polyene carboxylic acids, vitamins and minerals. Herbal substances of antioxidant action obtained on the basis of Kazakhstani plants are presented and described. The allocated herbal substances are notable by their bioavailability, low toxicity, absence of allergic reactions and cumulative effects, possibility of their long-term use for treatment and prevention of diseases.References
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2 Kehrer J.P., Robertson J.D. and Smith C.V. Free Radicals and Reactive Oxygen Species // Comprehensive Toxicology. – 2010. – Vol. 1. – P. 277-307.
3 Halliwel B. Reactive Species and Antioxidants. Redox Biology Is a Fundamental Theme of Aerobic Life // Plant. Physiology. – 2006. – Vol. 141. – Р. 312-322.
4 Halliwel B. Antioxidants in human health and disease // Ann.Rev.Nutr. – 1996. – Vol. 16. – P. 33-50.
5 Valko M., Leibfritz D., Moncola J., Cronin M.T.D., Mazur M., Telser J. Free radicals and antioxidants in normal physiological functions and human disease // The International Journal of Biochemistry & Cell Biology. – 2007. – Vol. 39. – Р. 44-84.
6 Storz P. Reactive oxygen species in tumor progression // Front. Biosci. – 2005. – Vol. 10. – Р. 1881-1896.
7 Rice-Evans C.A., Diplock A.T. Current status of antioxidant therapy // Free Radic.Biol.Med. – 1993. – Vol. 15. – No. 1. – P.77-96.
8 Sies H. Oxidative stress: Oxidants and antioxidants // Exp.Physiol. – 1997. – Vol. 82. – No. 2. – P. 291-295.
9 Cuzzorcrea S., Thiemermann C., Salvemini D. Potential therapeutic effect of antioxidant therapy in shock and inflammation // Curr.Med.Chem. –2004. – Vol. 11. – Р. 1147-1162.
10 Manach C., Scalbert A., Morand C., Rémésy C. and Jiménez L. Polyphenols: food sources and bioavailability // Am. J. Clin.Nutrition. – 2004. – Vol. 79. – No. 5. – P. 727-747.
11 Boudet A.M. Evolution and current status of research in phenolic compounds // Phytochemistry. – 2007. – Vol. 68. – No. 22-24. – P. 2722-2735.
12 Manach C., Mazur A., Scalbert A. Polyphenols and prevention of cardiovascular diseases // Curr. Opin. Lipidol. – 2005. – Vol. 16. – No. 1. – P.77-84.
13 Arts I.C., Hollman P.Ch. Polyphenols and disease risk in epidemiologic studies // Am. J. Clin. Nutr. – 2005. – Vol. 81. – No. 1. – P. 317S-325S.
14 Zhusupova G.E., Abilkaeva S.A. Dimeric prodelphinidins from Limonium gmelinii roots. III // Chemistry of Natural Compounds. – 2006. – No. 2. – P. 134-138.
15 Lin J.K., Liang Y.C. Cancer chemoprevention by tea polyphenols // Proc. Natl. Sci. Counc. – 2000. – Vol. 24. – P. 1-13.
16 Scalbert A. Antimicrobial properties of tannins // Phytochem. – 1991. – Vol. 30. – No. 12. – P. 3875-3883.
17 Verstraeten S.V., Keen C.L., Schmitz H.H., Fraga C.G. and Oteiza P.I. Flavan-3-ols and procianidins protect liposomes against lipid oxidation and disruption of the bilayer structure // Free Radic. Biol. Med. – 2003. – Vol. 34. – No. 1. – P. 84-92.
18 Nagai T., Miyachi Y., Tomimori T., Yamada H. Inhibition of influenza virus sialidase and antiinfluenza virus activity by plant flavonoids // Chem. Pharm. Bull. – 1990. – Vol. 5. – 38. – P. 1329-1332.
19 Vengerovskyi А.I., Saratikov А.S. Mechanism of action of hepatoprotectors under toxic liver damage // Pharmacology and toxicology. – 1988. – No. 1. – P. 89.
20 Zhusupova G.E., Abilkaeva S.A. Dimeric prodelphinidins from Limonium gmelinii roots. III // Chemistry of Natural Compounds. – 2006. – No. 2. – P. 134-138. http://dx.doi.org/10.1007/s10600-006-0068-8.
21 Zhanar A. Kozhamkulova, Galiya E. Zhusupova, Zharilkasin A. Abilov, Mohamed M. Radwan, Samir A. Ross. A new flavonol glycoside from Limonium gmelinii // Planta medica. – 2010. – Р. 534-535.
22 Petereit F., Kolodziej H., Nahrsted A. Flavan-3-ols and proanthocyanidins from Cistus incanus // Phytochem. – 1991. – Vol. 30. – No. 3. – P. 981-985.
23 Kala C.P., Farooquee N.A., Dhar U. Prioritization of medicinal plants on the basis of available knowledge, existing practices and use value status in Uttaranchal, India // Biodiver. Conserv. – 2004. – Vol. 13. – No. 2. – P. 453-469.
24 Gorgoshidze L.Sh., Kon’ I.Ya., Kulakov S.N., Shevyakov А.N. Lipid peroxidation in the rats liver under light forms of vitamin A deficiency // Nutrition. – 1986. – Vol. 5. – P. 45-51
25 Ohkawa H.O., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction // Anal.Biochem. – 1979. – Vol. 95. – No. 2. – P. 351-358.
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Gadetskaya, A. V., A. I. Zhussupova, T. M. Shalakhmetova, M. K. Murzakhmetova, and G. E. Zhussupova. 2015. “Natural Antioxidants of Plant Origin”. International Journal of Biology and Chemistry 8 (1):67-72. https://doi.org/10.26577/2218-7979-2015-8-1-67-72.
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