Transdermal study of hydrogel ointments and bandages with antituberculosis activity

Authors

  • M. S. Buribayeva Al-Farabi Kazakh National University, Kazakhstan, Almaty
  • A. Kunakbayeva Al-Farabi Kazakh National University, Kazakhstan, Almaty
  • L. Abebova Al-Farabi Kazakh National University, Kazakhstan, Almaty
  • G. S. Irmukhametova Al-Farabi Kazakh National University, Kazakhstan, Almaty
  • K. B. Muldagulova Al-Farabi Kazakh National University, Kazakhstan, Almaty
  • G. A. Mun Al-Farabi Kazakh National University, Kazakhstan, Almaty

DOI:

https://doi.org/10.26577/2218-7979-2015-8-1-73-78
        75 54

Keywords:

transdermal therapeutic system, drug delivery, polyvinylpyrrolidone, isoniazid, ethambutol, carbomer

Abstract

Transdermal study for hydrogel ointments and bandages based on polyvinylpirrolidone was conducted for application as transdermal therapeutic drug delivery systems for skin tuberculosis treatment. The ointments and bandages based on polyvinylpyrrolidone (PVP) and carbomer with drugs isoniazid and ethambutol were obtained. The transdermal characteristics were investigated using cellulose membrane and pig skin. The experiment was carried out by the device Franz cell and diffusion coefficient (D), permeability (P) and permeation rates (F) of the drugs were calculated. It was established that the rate of isoniazid penetration through the skin faster than that for ethambutol which is related to the structure peculiarities of drugs. The higher transdermal activity of hydrogel ointments was shown in comparison with hydrogel dressings. Also the prolongation effect of developed transdermal drug delivery systems based on PVP and carbomer was observed.

References

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How to Cite

Buribayeva, M. S., A. Kunakbayeva, L. Abebova, G. S. Irmukhametova, K. B. Muldagulova, and G. A. Mun. 2015. “Transdermal Study of Hydrogel Ointments and Bandages With Antituberculosis Activity”. International Journal of Biology and Chemistry 8 (1):73-78. https://doi.org/10.26577/2218-7979-2015-8-1-73-78.

Issue

Vol. 8 No. 1 (2015): International Journal of Biology and Chemistry

Section

Chemistry

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