Features of mir-466-3p binding sites in mRNA genes with different functions
DOI:
https://doi.org/10.26577/2218-7979-2015-8-2-44-51Keywords:
binding, sites, genesAbstract
The importance of miRNA in cellular regulation is gaining momentum. We searched miRNA binding sites using the MirTarget program. We identified several miRNAs that have greater than 300 target genes in humans, with multiple binding sites per gene. We observed that miR-466-3p 1,463 binding sites with high affinity (with ΔG/ΔGm values greater than or equal to 90%).References
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2. Ivashchenko A., Berillo O., Pyrkova A., Niyazova R., Atambayeva Sh. Binding sites of mir-1273 family on the mRNA of target genes. // Biomed
research international. – 2014. – P. 1-8.
3. Ivashchenko A., Berillo O., Pyrkova A., Niyazova R., Atambayeva Sh. The properties of binding sites of miR-619-5p, miR-5095, miR-5096 and miR-5585-3p in the mRNAs of human genes. // Biomed research international. – 2014. – P. 2014.
4. Ivashchenko A., Berillo O., Pyrkova A., Niyazova R., Atambayeva Sh. MiR-3960 binding sites with mRNA of human genes. // Bioinformation. –
2014. – Vol. 10. – No. 7. – P. 423-427.
5. Cheng Q., Yi B., Wang A., Jiang X. Exploring and exploiting the fundamental role of microRNAs in tumor pathogenesis. // Onco Targets Ther. – 2013. – Vol. 6. – P. 1675-1684.
6. Hromadnikova I., Kotlabova K., Hympanova L., Krofta L. Cardiovascular and cerebrovascular desease associated microRNAs are dysregulated in placental tissues affected with gestational hypertension,
preeclampsia and intrauterine growth restriction. // Plos One. – 2015. – Vol. 10 – No. 9. – e0138383.
7. Faruq O., Vecchione A. microRNA: Diagnostic perspective. // Front Med. – 2015. – 2. – P. 51.
8. Kool E.T. Hydrogen bonding, base stacking, and steric effects in DNA replication. // Annu.Rev. Biophys.Biomol.Struct. – 2001. – Vol. 30. – P. 1–22.
9. Leontis N.B., Stombaugh J., Westhof E. The non-Watson-Crick base pairs and their associated isostericity matrices. // Nucleic Acids Res. – 2002. – Vol. 30. – P. 3497–3531.
10. Ivashchenko A., Berillo O., Pyrkova A., Niyazova R., Atambayeva S. MiR-3960 binding sites with mRNA of human genes. // Bioinformation. –
2014. – Vol. 10. – No. 7. – P. 423-427.
11. Berillo O., Atambayeva Sh., Niyazova R., Akimniyazova A., Ivashchenko A., Pyrkova A. Features of Multiple MiR-574-5р Binding Sites and Functions of Their Target-Genes. // Journal of Bioinformatics
and Computational Biology. – submitted for publication.
12. Druz A., Chu C., Majors B., Santuary R., Betenbaugh M., Shiloach J. A novel microRNA mmu-miR-466h affects apoptosis regulation in mammalian cells. // Biotechnol Bioeng. – 2011. – Vol. 108. – P. 1651-1661.
13. Dimmeler S., Zeiher A.M. Endothelial cell apoptosis in angiogenesis and vessel regression. // Circ Res. – 2000. – Vol. 87. – P. 434-439.
14. Folkman J. Angiogenesis and apoptosis. // Semin Cancer Biol. – 2003. – 13. – P. 159-167.
15. Druz A., Betenbaugh M., Shiloach J. Glucose depletion activates mmu-miR-466h-5p expression through oxidative stress and inhibition of histone deacetylation. // Nucleic Acids Res. – 2012. – Vol. 40. – P. 7291-7302.
16. Li Y., Fan X., He X., Sun H., Zou Z., Yuan H., Xu H., Wang C., Shi X. MicroRNA-466 inhibits antiviral innate immune response by targeting interferon-alpha. // Cell Mol Immunol. – 2012. – Vol. 9. – P. 497-502.
17. Luo Y., Liu Y., Liu M., Wei J., Zhang Y., Hou J., Huang W., Wang T., Li X., He Y., Ding F., Yuan L., Cai J., Zheng F., Yang J. Sfmbt2 10th intron-
hosted miR-466(a/e)-3p are important epigenetic regulators of Nfat5 signaling, osmoregulation and urine concentration in mice. // Biochim Biophys Acta. – 2014. – Vol. 1839. – P. 97-106.
18. Seo M., Choi J., Rae Rho Ch., Joo Ch., Lee S. Microrna Mir-466 inhibits lymphangiogenesis by targeting Prospero-related homeobox 1 in the alkali burn corneal injury model. // Journal of Biomedical
Science. – 2015. – Vol. 22. – P. 3.
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How to Cite
Niyazova, R., Sh. Atambayeva, A. Akimniyazova, I. Pinsky, A. Alybaeva, B. Faye, and A. Ivashchenko. 2015. “Features of Mir-466-3p Binding Sites in MRNA Genes With Different Functions”. International Journal of Biology and Chemistry 8 (2):44-51. https://doi.org/10.26577/2218-7979-2015-8-2-44-51.
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