Phenolic profiles and brine shrimp cytotoxicity of the ethanolic extract from the aerial part of Crocus alatavicus L.

Abstract

The aim of this study is to investigate the phenolic profiles and evaluate the brine shrimp cytotoxic activity of the ethanolic extract from the aerial part of C. alatavicus, an endemic species of Kazakhstan flora. Nine phenolic compounds were identified and quantified in the extract by high-performance liquid chromatography method. Preliminary cytotoxicity of the extract was determined by the brine shrimp (Artemiasalina) assay. The results reveal that the ethanolic extract from the aerial part of Crocus alatavicus exhibit a high cytotoxicity with LC50 15.71 μg/mL.