Development of hydrogel ointments based on carbopol with α-lipoic acid

Abstract

This article presents the results of hydrogel ointments development based on carbopol polymer with α-lipoic acid for their application as transdermal therapeutic delivery systems for antibacterial treatment of diabetic foot syndrome. Complex formation of bioavailable α-lipoic acid with hydroxypropyl-β-cyclodextrin was studied using differential scanning calorimetry and scanning electron microscopy. Optimal rheological characteristics of obtained ointments have been estimated. Antimicrobial activity in relation to Staphylococcus aureus and Escherichia coli have been observed for ointments containing α-lipoic acid. Transdermal drug delivery properties of obtained hydrogel ointments were investigated using cellulose membrane as a model system and a pig skin.