Myeloid poiesis stimulating activity of azaheterocycles compound of the dimethyl ether of P-(4-methoxyphenyl)-1-(4-phenylpiperazine) methyl] phosphonic acid

  • L. K. Baktybayeva Laboratory of ecological physiology
  • M. K. Tauassarova Laboratory of ecological physiology
  • B. K. Kairat Laboratory of ecological physiology
  • B. K. Darrell Oklahoma State University
  • N. B. Baktybay Laboratory of ecological physiology
  • V. K. Yu A.B. Bekturov Institute of Chemical Sciences
  • A. G. Zazybin A.B. Bekturov Institute of Chemical Sciences
  • A. E. Malmakova A.B. Bekturov Institute of Chemical Sciences

Abstract

Development of new effective drugs with myeloid poiesis stimulating activity is highly relevant due to the increase in the number of patients with hematological disorders. Acquired hematological diseases are associated with unbalanced and inadequate nutrition, chronic blood loss, living in ecologicallydisadvantaged areas, extreme physical activity, use of cytostatic and cytotoxic drugs, chronic stress, and other. Azaheterocyclic compounds are perspective for search of new effective myeloid poiesis stimulating drugs. The incentive for this search was the manifestation of myeloid poiesis stimulating activity byazaheterocycles drug Prosidol (Propionylphenylethoxyethylpyperidine) in clinical practice. On the model cyclophosphamide myeloid depression high myeloid poiesis stimulating activity showed that compound of the dimethyl ether of P-(4-methoxyphenyl)-1-(4-phenylpiperazine) methyl] - phosphonic acid in laboratory coding of BIV-95. In a series of experiments showed myeloid poiesis stimulating activity at the level of comparison compound (2, 3, 5, 6-tetrahydro-6-phenylimidazo [2, 1-b] thiazole hydrochloride (Levamizol drug). The erythropoiesis stimulating activity exceeded the activity of the comparison compounds. The thrombocytopoiesis stimulating activity was at the level of the comparison compounds. Leukopoiesis stimulating activity also was slightly higher than the activity of Levamizol drug. Recovery of granulocytic and agranulocytic leukocyte were no violations of immunoregulatory index in leukogram blood. The testcompound is the dimethyl ether of P-(4-methoxyphenyl)-1-(4-phenylpiperazine) methyl]-phosphinic acid compound under the laboratory coding BIV-95 had low toxicity.

Author Biographies

V. K. Yu, A.B. Bekturov Institute of Chemical Sciences
Laboratory of chemistry of synthetic and natural drugs
A. G. Zazybin, A.B. Bekturov Institute of Chemical Sciences
Laboratory of chemistry of synthetic and natural drugs
A. E. Malmakova, A.B. Bekturov Institute of Chemical Sciences
Laboratory of chemistry of synthetic and natural drugs
Published
2019-08-07
How to Cite
BAKTYBAYEVA, L. K. et al. Myeloid poiesis stimulating activity of azaheterocycles compound of the dimethyl ether of P-(4-methoxyphenyl)-1-(4-phenylpiperazine) methyl] phosphonic acid. International Journal of Biology and Chemistry, [S.l.], v. 12, n. 1, p. 18-23, aug. 2019. ISSN 2409-370X. Available at: <https://ijbch.kaznu.kz/index.php/kaznu/article/view/364>. Date accessed: 18 sep. 2020. doi: https://doi.org/10.26577/ijbch-2019-1-i15.