Synthesis and theoretical activity evaluation of a new steroid-oxazolone derivative against COX1-1 and COX-2

  • L. Figueroa-Valverde University Autonomous of Campeche
  • M. Rosas-Nexticapa Universidad Veracruzana
  • F. Díaz-Cedillo Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional
  • T. Lopez-Gutierez University Autonomous of Campeche
  • M. López-Ramos University Autonomous of Campeche
  • L. Hau-Heredia University Autonomous of Campeche
  • E. Pool-Gómez Universidad Veracruzana
  • P. Hernandez-Vasquez Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional

Abstract

There are some reports for the preparation of several drugs as COX-inhibitors; however, some reagents used in the preparation are expensive and difficult to handle. The aim of this study was to synthesize a steroid-oxazolone derivative using some reactions such as i) hydroxylation-amiination; ii) amidation; iii) alkynyl-addition; iv) aldolization and iv) imination. In addition, a theoretical assessment was carried out to evaluate the interaction of both COX-1 and COX-2 with the steroid-oxazolone derivative using indomethacin and rofecoxib as controls in a docking model. The structure of the compounds obtained was confirmed through elemental analysis, spectroscopy and spectrometry data. The results showed that the steroid-oxazolone derivative has a higher affinity for COX 1 compared to indomethacin; however, it exhibits a lower affinity for COX-2 in comparison with rofecoxib. These data suggest that the steroid-oxazolone derivative could be a good candidate as COX-1 inhibitor translated as a possible drug for treatment of pain.

Author Biography

L. Figueroa-Valverde, University Autonomous of Campeche
Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences
Published
2019-08-09
How to Cite
FIGUEROA-VALVERDE, L. et al. Synthesis and theoretical activity evaluation of a new steroid-oxazolone derivative against COX1-1 and COX-2. International Journal of Biology and Chemistry, [S.l.], v. 12, n. 1, p. 135-145, aug. 2019. ISSN 2409-370X. Available at: <https://ijbch.kaznu.kz/index.php/kaznu/article/view/377>. Date accessed: 18 sep. 2020. doi: https://doi.org/10.26577/ijbch-2019-1-i18.