Effects of crude oil and its inorganic component (vanadium) on antioxidant enzymes in liver and kidneys of rats
Keywords:
Crude oil, Ciprofloxacin, Cytochrome P-450 1A, Lipid peroxidation, RatAbstract
Antioxidant defense were studied in liver and kidney of male albino rats received an aqueous solution of ammonium metavanadate (AMV; 0.30 mg V/mL) or/and crude oil (CO; 0.75 ml/kg bw ip)) for 21-day period. AMV or/and CO treatments resulted in a significant (P<0.001) induction in aminotransferases (ALT and AST) activities in serum, as well as lipid peroxidation in liver and kidney. Concomitantly significant (P<0.001) decline in superoxide dismutase (SOD) activity and glutathione (GSH) content was obtained. In AMV and AMV-CO treatments, glutathione-S-transferase (GST) activity significantly (P<0.001) reduced in liver and induced in kidney while in CO treatment, GST activity significantly (P<0.01) induced in liver and was unchanged in kidney. Signs of toxicity were observed in all vanadium-treated animals as evidenced by some deaths, decreased weight gain. These data indicated that kidney is more vulnerable to the caused by the AMV or/and CO-induced oxidative stress than liver as well as that the oxidative stress at co-exposure to AMV and CO may be more markedly advanced than at separate exposure.References
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2- Kalogeropoulos N, Scoullos M, Vassilaki-Grimani M, Grimanis AP. Vanadium in particles and sediments of the northern Saronikos Gulf, Greece. Sci Total Environ. 79: 241-252, 1989.
3- Vazquez F, Sanchez M, Alexander H, Delgado D. Distribution of Ni, V, and petroleum hydrocarbons in recent sediments from the Veracruz coast, Mexico. Bull Environ Contam Toxicol. 46:774 -781, 1991.
4- Zychlinski L. Toxicological appraisal of work-places exposed to the dust containing vanadium pentoxide. [Pol.]. Bromat. Chem. Toksykol. 8: 195-199, 1980.
5- Flyger H, Jensen FP, Kemp K. Air pollution in copenhagen. Part I. Element analysis and size distribution of aerosols. RISO Rep. Mar. 338: 1-70, 1976.
6- Stohs SJ, Bagchi D. Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med. 18: 321-36, 1995.
7- Chen F, Ding M, Castranova V, Shi X. Carcinogenic metals and NF-kappa B activation. Mol Cell Biochem. 222: 159-171, 2001.
8- Zaporowska H. Effect of vanadium on L-ascorbic acid concentration in rat tissues. Gen Pharmacol. 25: 467-470, 1994.
9- Khan AA, Coppock RW, Schuler MM, Geleta L. Biochemical changes as early stage systemic biomarkers of petroleum hydrocarbon exposure in rats. Toxicol Lett. 134: 195-200, 2002.
10- Burlakova EB, Аlesenko AV, Molochkina EM, Palmina NP, Khrapova NG. 1975. Bioantioxidants for radiation damage and malignant growth. Nauka, Moscow, 214p.
11- Baker MA, Cerniglia GJ, Zaman A. Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples. Anal. Biochem. 190: 360 – 365, 1990.
12- Marklund S. Distribution of CuZn superoxide dismutase and Mn superoxide dismutase in human tissues and extracellular fluids. Acta Physiol. Scand. Suppl., 492: 19 – 23, 1980.
13- Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases: the first enzymatic step in mercapturic acid formation. J. Biol.Chem., 249: 7130–7139, 1974.
14- Landu S, Everitt BS. A handbook of statistical Analyses using SPSS. Chapman and Hall/CRC press LLC. London, p. 337, 2004.
15- Thompson KH, McNeill JH. Effect of vanadyl sulfate feeding on susceptibility to peroxidative change in diabetic rats. Res Commun Chem Pathol Pharmacol. 80:187-200, 1993.
16- Timbrell JA. Principles of Biochemical Toxicology, (2nd Edn). Taylor and Francis, London, 1991.
17- Scibior A, Zaporowska H. Effects of combined vanadate and magnesium treatment on erythrocyte antioxidant defence system in rats. Environ Toxicol Pharmacol. 30: 153-161, 2010.
18- Byczkowski JZ, Channel SR. chemically induced oxidative stress and tumorigenesis: effects on signal transduction and cell proliferation. Toxic Subst. Mechan., 15: 101-128, 1996.
19- Younes M, Kayser E, Strubelt O. Effect of antioxidants on vanadate-induced toxicity towards isolated perfused rat livers. Toxicology, 70: 141–149, 1991.
20- Russanov E, Zaporowska H, Ivancheva E, Kirkova M, Konstantinova S. Lipid peroxidation and antioxidant enzymes in vanadate-treated rats. Comp Biochem Physiol Pharmacol Toxicol Endocrinol. 107: 415- 421, 1994.
21- Khan AA, Coppock RW, Schuler MM. Effects of multiple exposures of small doses of Pembina Cardium crude oil and diesel in rats. Arch Environ Contam Toxicol. 40: 418-424, 2001.
22- Halliwell B. Reactive oxygen species and the central nervous system. J Neurochem. 59: 1609-1623, 1992.
23- Liu J, Mori A. Involvement of reactive oxygen species in emotional stress: A hypothesis based on the immobilization stress-induced oxidative damage and antioxidant defense changes in rat brain, and the effect of antioxidant treatment with reduced glutathione. Int. J. Stress Mgt. 1: 249 – 263, 1994.
24- Soussi A, Croute F, Soleilhavoup JP, Kammoun A, El-Feki A. Impact of green tea on oxidative stress induced by ammonium metavanadate exposure in male rats. C R Biol., 329: 775-784, 2006.
25- Chandra AK, Ghosh R, Chatterjee A, Sarkar M. Effects of vanadate on male rat reproductive tract histology, oxidative stress markers and androgenic enzyme activities. J. Inorg. Biochem. 101: 944–956, 2007.
26- Mates JM, Perez-Gomez C, Núñez de Castro I. Antioxidant enzymes and human diseases. Clin. Biochem., 32: 595-603, 1999.
27- Arrigo AP. Gene expression and the thiol redox state. Free Radic Biol Med., 27: 936-44, 1999.
28- Uyanık F, Eren M, Atasever A, Tunçoku G, Kolsuz AH. Changes in Some Biochemical Parameters and Organs of Broilers Exposed To Cadmium and Effect of Zinc on Cadmium Induced Alterations. Israel J. Vet. Med. 56: 128-134, 2001.
29- Chiapotto e, Biasi f, Scavazza A, Camandola S, Aragno M, Tamagno E, Danni O, Dianzan MU, Poli G. Acetaldehyde involvement in ethanol induced potentiation of rats hepatocyte damage due to the carcinogen 1, 2 – dibromoethanol. Alcohol and Alcoholism, 30: 721-728, 1995.
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Published
2012-06-20
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Shalahmetova, T. M., K. E. Mahmoud, and Sh. N. Deraz. 2012. “Effects of Crude Oil and Its Inorganic Component (vanadium) on Antioxidant Enzymes in Liver and Kidneys of Rats”. International Journal of Biology and Chemistry, no. 3 (June):27-33. https://ijbch.kaznu.kz/index.php/kaznu/article/view/48.
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