Biological activity of 4-ethynyl-, 4-oxy-, 4-butoxypropylpyperidine and azaheterocyclic compounds


  • G. Daulet Аl-Farabi Kazakh National University
  • L. Baktybayeva Аl-Farabi Kazakh National University
  • A. Sokolenko Аl-Farabi Kazakh National University
  • V. Yu A.B. Bekturov Institute of Chemical Sciences
  • A. Malmakova A.B. Bekturov Institute of Chemical Sciences
  • A. Ten A.B. Bekturov Institute of Chemical Sciences
  • K. Berlin Oklahoma State University
  • G. Zazybin Kazakh-British Technical University
  • N. Belyaev Saint-Petersburg Pasteur Institute



The new chemical series of compounds is promising for the search new effective immunostimulating drugs. Acute toxicity and the effect on peripheral blood hemogram parameters and on the subpopulation composition of lymphocytes were determined in the compounds (piperidine-containing derivatives): 1-(3-n-butoxypropyl)-piperidine-3-methyl-4-spiro-5'-imidazolidine-2',4'-dione,1-(2-ethoxyethyl)-4-carboxy-4-hydroxypiperidine, bis[1-(2-ethoxyethyl)-4-ethynyl-4-hydroxypiperidine) dihydrochloride and, 1:1 complexes of β-cyclodextrin with 1-(2-ethoxyethyl)-4-(2-ethoxyethoxyl)-4-ethynylpiperidine, 1-(2-ethoxyethyl)-4-(2-methoxyethoxyl)-4-ethynylpiperidine, 7-(2-methoxyethyl)-2,2-dimethyl-3-thia-7-azabicyclo[3.3.1]nonane or 3-(2-morpholinoethyl)-7-(3-isopropoxypropyl) diazabicyclo[3.3.1] nonane with β-cyclodextrin. Compound ˗ 1-(3-n-butoxypropyl)piperidine-3-methyl-4-spiro-5'-imidazolidine-2',4'-dione, exceeds the immunostimulating activity of the comparison drug of levamizole by 3,1 times and has low toxicity.