Study of the distribution of the coordinating compound C11H12N2O2•(C11H13N2O2)+•NA+•2Н2О•(I4)2- in mice organism by radioisotope method

Authors

  • S. Turganbay JSC «Scientific Center for Anti-Infectious Drugs»
  • A. Sabitov JSC «Scientific Center for Anti-Infectious Drugs»
  • M. Liu JSC “Scientific Center for Anti-Infectious Drugs”
  • M. Zhumabaev JSC “Scientific Center for Anti-Infectious Drugs”
  • S. Kasimbekova JSC “Scientific Center for Anti-Infectious Drugs”

DOI:

https://doi.org/10.26577/ijbch.2021.v14.i1.010

Abstract

The paper presents the results of studies on the effect of a new synthesized coordination compound based on an amino acid-tryptophan and iodine compounds on bacterial DNA and the kinetics of its distribution in mice tissues after a single intravenous or oral administration. A radiochemical study of the quantitative content of the coordination compound labeled with iodine-131 in the system of laboratory mice after intravenous and oral administration showed the presence of an isotopic label in the tissues and organs under study. The coordination compound has the ability to accumulate in internal organs and tissues in various concentrations with a further decrease by 24 hours (study period) and clearance of the drug from the body. The effect of a solution of a coordination compound labeled with the 131I isotope on the E. coli culture ATCC 25922 showed that DNA halogenation occurs due to the breakdown of the tryptophan-tetraiodide iodine complex in the cell with the formation of molecular iodine.

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Published

2021-07-02