Genetic effects of phenylpyrazoles on Citellus fulvus from biotopes of South Kazakhstan
Keywords:
genotoxical effects, Citellus fulvus, pesticide treatmentsAbstract
It was investigated of genotoxical effects of fipronil, that is widely used in Kazakhstan, on background rodents from South Kazakhstan biotopes, where widely used phenylpyrazoles insecticides. The frequency of chromosomal and genomic mutations in bone marrow cells of Citellus fulvus from Arys and Shardara areas were significantly higher (Р<0.01) than in rodents from Kazygurt area, that is furthest from the pesticide treatments. High level of chromatid aberrations are indicative for the presence of chemical mutagens. It was determined fipronil and it’s degradation to fipronil-sulfone metabolite in Citellus fulvus from biotopes of South Kazakhstan, where used phenylpyrazoles pesticides.References
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2. Bersimbaev, R.I. Chromosome aberrations in occupational uranium miners of North Kazakhstan // 8th International Conference on Enviromental Mutagens «Fundamental and Molecular mechanisms of Mutagenesis». - Shizuoka, 2001. - P.178.
3. Bersimbaev, R.I. The family analysis of the chromosome aberration frequencis in the population of the Semipalatinsk nuclear test site // 8th International Conference on Enviromental Mutagens «Fundamental and Molecular mechanisms of Mutagenesis». - Shizuoka, 2001. - P.59.
4. Bigaliev, A.B., Abilev, S.K. Genetic and environment. - Karaganda: KSU, 1989. - 141 p.
5. CAS Registry Number and substance Counts, 2008 // http://www.cas.org/cgi-bin/regrepot.pl.
6. Garsia, H.J.M. Effect of difenzogyat herbicide on cell division of wheat root tips // Physiol. Plant. - 1990. - Vol. 2. - P. 49-54.
7. Patil, T.M., Shirashya, V.S. Effect of methylparation and phosphamiden an mitotic chromosomal aberrations in some vegetable seeds // Environ. Biol. - 1991. - Vol. 3. - P. 249-254.
8. Holland, N.T. et al. Micronucleus frequency and proliferation in human lymphocytes after exposure to herbicide 2,4-dichlorophenoxyacetic acid in vitro and in vivo // Mutation Research (Genetic Toxicology and Environmental Mutagenesis). - 2002. - Vol. 521. - P. 165-178.
9. González, M. et al. Effect of dithiocarbamate pesticide zineb and its commercial formulation, azzurro. IV. DNA damage and repair kinetics assessed by single cell gel electrophoresis (SCGE) assay on Chinese hamster ovary (CHO) cells // Mutation Research (Genetic Toxicology and Environmental Mutagenesis). - 2003. - Vol. 534. - P. 145-154.
10. Mahata, J. et al. Chromosomal aberrations and sister chromatid exchanges in individuals exposed to arsenic through drinking water in West Bengal, India // Mutation Research (Genetic Toxicology and Environmental Mutagenesis). - 2003. - Vol. 534. - P. 133-143.
11. Sharma, C.B.S.R. On the relative validity of the barley cytogenetic system as a monitor of pesticide mutagenecity // Environ. Mutagenes - 1982. - Vol. 4, № 3. - P. 329-335.
12. Insecticide factsheet. Fipronile // Journal of Pesticide Reform. - 2005. - Vol. 25, № 1. - P. 10-15.
13. Information bulletin RK. – Almaty, 2002. - 159 p.
14. Sagitov, A.O. et al. The prognostication of a volume of chemical treatment against Locusts in Kazakhstan // Protection and quarantine of plants. - 2002. - № 1. - P. 19-20.
15. Hainzl, D., Cole, L.M., Casida, J.E. Mechanisms for selective toxicity of fipronil insecticide and its sulfone metabolite and desulfinyl photoproduct // Chem. Res. Toxicol. - 1998. - Vol. 11. - P. 1529-1535.
16. Grafodatsky, A.S., Radgably, S.I. Chromosomes of agricultural and laboratorial animals. - Novosibirsk: Science, 1988. - 127 p.
17. Vilchez, J.L. et al. Determination of fipronil by solid-phase microextraction and gas chromatography-mass spectrometry // J. Chromatogr. A. - 2001. - Vol. 919. - P. 215-221.
18. The determination of fipronil and fipronil-sulfone in water, soil, potatoes, seeds by gas-liquid chromatography. Metodical protocols. MUK 4.1.1400-03: MSSD of RF 24.06.2003. – Moskow, 2003. – 31 p.
19. Zhou, P. et al. Dynamics of fipronil residue in vegetable-field ecosystem // Chemosphere. – 2004. - № 57. - Р. 1691-1696.
20. Rokitsky N.A. Introduction in statistical genetics. – Minsk: Higher school, 1978. - 448 p.
21. Dmitriev, Z.G. Cytogenetical unstability of three species of rodents in chemical plant of North Russia // Ecology. - 1997. - № 6. - P. 447-451.
22. Dubinin, N.P. Common genetic – Moskow: Science, 1986. - 559 p.
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Published
2012-06-20
How to Cite
Begymbetova, D. A., S. Zh. Kolumbaeva, and A. V. Lovynskaya. 2012. “Genetic Effects of Phenylpyrazoles on Citellus Fulvus from Biotopes of South Kazakhstan”. International Journal of Biology and Chemistry, no. 3 (June):71-75. https://ijbch.kaznu.kz/index.php/kaznu/article/view/56.
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