Experience in production of 18F isotope in the Cyclone-30 for synthesis of fluorinated radiopharmaceuticals

Abstract

This article provides a brief overview of the ¹⁸F isotope production using the Cyclone-30 cyclotron and two liquid targets with the volume of 0.5 and 2.0 ml, water enriched with the ¹⁸O isotope was used as the target material. The obtained isotope was used for serial production of the [¹⁸F]FDG radiopharmaceutical and supply of this medicine to the operating PET centers in Almaty. The isotope was also used for experimental syntheses of [¹⁸F]PSMA-1007 and Na[¹⁸F]F to assess the possibility of implementation these medicines into the production and medical practice of the Republic of Kazakhstan. The need for the implementation of [¹⁸F]PSMA-1007 is associated with the problem of early diagnosis and control of prostate cancer treatment, and Na[¹⁸F]F - with the earliest possible detection of bone metastases in malignant tumors of various localization. This paper provides the average radiochemical yield and the main quality parameters for [¹⁸F]FDG, [¹⁸F]PSMA-1007 and Na[¹⁸F]F. This scientific and practical work allows us to evaluate the three-year production experience and the possibilities of fluorine production by reaction (p,n) on the cyclotron С-30, and also reflects the prospects of using fluorine in the development of new-generation radiopharmaceuticals for the diagnosis of oncological diseases.