Effect of the complex extract from Rumex plants on quantitative parameters of blood cells and bone marrow in vivo

Authors

  • A.K. Shokan Al-Farabi Kazakh National University; Institute of Genetics and Physiology, Almaty, Kazakhstan
  • D.M. Yergozova Al-Farabi Kazakh National University; Institute of Genetics and Physiology, Almaty, Kazakhstan
  • T.N. Kobylina Al-Farabi Kazakh National University; Institute of Genetics and Physiology, Almaty, Kazakhstan
  • N.O. Kudrina Al-Farabi Kazakh National University; Institute of Genetics and Physiology, Almaty, Kazakhstan
  • Yu.A. Litvinenko Al-Farabi Kazakh National University; Institute of Genetics and Physiology, Almaty, Kazakhstan
  • G.A. Seitimova Al-Farabi Kazakh National University; Institute of Genetics and Physiology, Almaty, Kazakhstan
  • T.E. Kulmanov Al-Farabi Kazakh National University; Institute of Genetics and Physiology, Almaty, Kazakhstan
  • N.V. Terletskaya Al-Farabi Kazakh National University; Institute of Genetics and Physiology, Almaty, Kazakhstan
  • I.M. Zharkova Al-Farabi Kazakh National University, Almaty, Kazakhstan

DOI:

https://doi.org/10.26577/IJBCh2024v17i1-a4
        52 81

Abstract

Assessment of the composition of peripheral blood cells and red bone marrow in preclinical studies is a key component of program for analysis of biologically active compounds obtained from the plant materials. Current study concerns effect of the complex extract from Rumex plants (R. confertus, R. tianschanicus, R. thyrsiflorus) on parameters of blood cells and bone marrow of laboratory animals. During the study, data were obtained on the effect of the extract on hematopoiesis when administered at 100 mg/kg of animal weight. The results obtained show that application of the extract is accompanied by a statistically significant increase in the number of neutrophil precursors, such as myeloblasts and band neutrophils (p≤0.05). According to our results the extract we obtained from Rumex plants does not cause inhibition of early bone marrow precursors and is safe and non-toxic.

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How to Cite

Shokan, A.K., D.M. Yergozova, T.N. Kobylina, N.O. Kudrina, Yu.A. Litvinenko, G.A. Seitimova, T.E. Kulmanov, N.V. Terletskaya, and I.M. Zharkova. 2024. “Effect of the Complex Extract from Rumex Plants on Quantitative Parameters of Blood Cells and Bone Marrow in Vivo”. International Journal of Biology and Chemistry 17 (1):31-39. https://doi.org/10.26577/IJBCh2024v17i1-a4.