Synthesis and mucoadhesive study of thiolated hydrogels based on 2-hydroxyethylacrylate and 2-hydroxyethylmethylacrylate copolymers

  • D. S. Kazybayeva Al-Farabi Kazakh National University, Almaty
  • A. Nurzhanova Al-Farabi Kazakh National University, Almaty
  • G. S. Irmukhametova Al-Farabi Kazakh National University, Almaty
  • G. A. Mun Al-Farabi Kazakh National University, Almaty

Abstract

Hydrogels and copolymers of 2-hydroxyethylmethacrylate and 2-hydroxyethylacrylate structured with 3-mercaptopropyltrimethoxysilane nanoparticles of different composition and nanoparticles concentration have been synthesized and characterized using IR-spectroscopy, SEM, small angle X-ray scattering, compression mechanical test, thermogravimetric analysis, iodometry. Mucoadhesive properties of obtained hydrogels were investigated. Study revealed that increase in concentration of hydrophilic component, nanoparticles content and crosslinking agent concentration reflects an increase of adhesion time of obtained hydrogel materials. Drug loading and drug release studies of HEA-HEMA-MPTS samples with metronidazole were conducted. It was observed that thiolated samples absorb more drug amount than non-thiolated ones. As nanoparticles concentration increases metronidazole content rises respectively. Drug release studies revealed that the higher concentration of 3-MPTS nanoparticles in hydrogels results in prolongation of drug release but concentration of discharged metronidazole decreases.

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How to Cite
KAZYBAYEVA, D. S. et al. Synthesis and mucoadhesive study of thiolated hydrogels based on 2-hydroxyethylacrylate and 2-hydroxyethylmethylacrylate copolymers. International Journal of Biology and Chemistry, [S.l.], v. 9, n. 1, p. 52-61, june 2016. ISSN 2409-370X. Available at: <http://ijbch.kaznu.kz/index.php/kaznu/article/view/212>. Date accessed: 20 nov. 2017.
Section
Chemistry

Keywords

organosilane thiol nanoparticles; hydrogels; mucoadhesion; 3-mercaptopropyltrimethoxysilane